Specific Structural Determinants Are Responsible for the Antioxidant Activity and the Cell Cycle Effects of Resveratrol*

@article{Stivala2001SpecificSD,
  title={Specific Structural Determinants Are Responsible for the Antioxidant Activity and the Cell Cycle Effects of Resveratrol*},
  author={Lucia Anna Stivala and Monica Savio and Federico Carafoli and Paola Perucca and Livia Bianchi and Giovanni Maga and Luca Forti and Ugo Maria Pagnoni and Angelo Albini and Ennio Prosperi and Vanio Vannini},
  journal={The Journal of Biological Chemistry},
  year={2001},
  volume={276},
  pages={22586 - 22594}
}
Resveratrol (3,4′,5-trihydroxy-trans-stilbene) is a natural phytoalexin found in grapes and wine, which shows antioxidant and antiproliferative activities. In this study we have investigated whether these properties are dependent on similar or different structural determinants of the molecule. To this purpose, resveratrol derivatives, in which all or each single hydroxylic function were selectively substituted with methyl groups, were synthesized. Analogues with the stilbenic double bond… Expand
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Up to the present, conclusive evidence for its absorption by human subjectsin biologically significant amounts is lacking, and it is questionable that its powerful and beneficial in vitro activities are reproduced as a consequence of sustained moderate red wine consumption. Expand
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The decrease of resveratrol production during maturation was confirmed by the fact that there is a clear negative correlation between the resver atrol content of grape skin and the developmental stage of berries measured by the sugar concentration of juice. Expand
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The data show that, like flavonoids, resveratrol protects LDL against peroxidative degradation by both chelating and free radical scavenging mechanisms, and was less potent than flavonoid (but more than trolox) as a scavenger of free radicals. Expand
Effect of antioxidants, resveratrol, quercetin, and N‐acetylcysteine, on the functions of cultured rat hepatic stellate cells and kupffer cells
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NAC and these phenolic compounds may have therapeutic potential against liver injury by regulating functions of cultured rat hepatic stellate cells and Kupffer cells. Expand
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TLDR
Data indicate that resveratrol inhibits lipid peroxidation mainly by scavenging lipid per oxyl radicals within the membrane, like α-tocopherol, and although it is less effective, its capacity of spontaneously entering the lipid environment confers on it great antioxidant potential. Expand
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