Specific Structural Determinants Are Responsible for the Antioxidant Activity and the Cell Cycle Effects of Resveratrol*

@article{Stivala2001SpecificSD,
  title={Specific Structural Determinants Are Responsible for the Antioxidant Activity and the Cell Cycle Effects of Resveratrol*},
  author={Lucia Anna Stivala and Monica Savio and Federico Carafoli and Paola Perucca and Livia Bianchi and Giovanni Maga and Luca Forti and Ugo Maria Pagnoni and Angelo Albini and Ennio Prosperi and Vanio Vannini},
  journal={The Journal of Biological Chemistry},
  year={2001},
  volume={276},
  pages={22586 - 22594}
}
Resveratrol (3,4′,5-trihydroxy-trans-stilbene) is a natural phytoalexin found in grapes and wine, which shows antioxidant and antiproliferative activities. In this study we have investigated whether these properties are dependent on similar or different structural determinants of the molecule. To this purpose, resveratrol derivatives, in which all or each single hydroxylic function were selectively substituted with methyl groups, were synthesized. Analogues with the stilbenic double bond… 

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