Specific Serotonergic Denervation Affects tau Pathology and Cognition without Altering Senile Plaques Deposition in APP/PS1 Mice

@inproceedings{RamosRodrguez2013SpecificSD,
  title={Specific Serotonergic Denervation Affects tau Pathology and Cognition without Altering Senile Plaques Deposition in APP/PS1 Mice},
  author={Juan Jos{\'e} Ramos-Rodr{\'i}guez and Sara Molina-Gil and Raquel Rey-Brea and Esther Berrocoso and Monica Garcia-Alloza},
  booktitle={PloS one},
  year={2013}
}
Senile plaques and neurofibrillary tangles are major neuropathological features of Alzheimer's Disease (AD), however neuronal loss is the alteration that best correlates with cognitive impairment in AD patients. Underlying neurotoxic mechanisms are not completely understood although specific neurotransmission deficiencies have been observed in AD patients and, in animal models, cholinergic and noradrenergic denervation may increase amyloid-beta deposition and tau phosphorylation in denervated… CONTINUE READING
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