Specific RNA residue interactions required for enzymatic functions of Tetrahymena telomerase.

@article{Gilley1996SpecificRR,
  title={Specific RNA residue interactions required for enzymatic functions of Tetrahymena telomerase.},
  author={David A Gilley and Elizabeth H Blackburn},
  journal={Molecular and cellular biology},
  year={1996},
  volume={16 1},
  pages={66-75}
}
The ribonucleoprotein enzyme telomerase is a specialized reverse transcriptase that synthesizes telomeric DNA by copying a template sequence within the telomerase RNA. Here we analyze the actions of telomerase from Tetrahymena thermophila assembled in vivo with mutated or wild-type telomerase RNA to define further the roles of particular telomerase RNA residues involved in essential enzymatic functions: templating, substrate alignment, and promotion of polymerization. Position 49 of the… CONTINUE READING

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Telomeres and telomerase.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences • 2004
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