Specific Polyunsaturated Fatty Acids Drive TRPV-Dependent Sensory Signaling In Vivo

  title={Specific Polyunsaturated Fatty Acids Drive TRPV-Dependent Sensory Signaling In Vivo},
  author={Amanda H. Kahn-Kirby and Jami L. M. Dantzker and Alfonso Junior Apicella and William R. Schafer and John Browse and Cornelia I Bargmann and Jennifer L Watts},
A variety of lipid and lipid-derived molecules can modulate TRP cation channel activity, but the identity of the lipids that affect TRP channel function in vivo is unknown. Here, we use genetic and behavioral analysis in the nematode C. elegans to implicate a subset of 20-carbon polyunsaturated fatty acids (PUFAs) in TRPV channel-dependent olfactory and nociceptive behaviors. Olfactory and nociceptive TRPV signaling are sustained by overlapping but nonidentical sets of 20-carbon PUFAs including… CONTINUE READING


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