Specific Inhibition of the VEGFR-3 Tyrosine Kinase by SAR131675 Reduces Peripheral and Tumor Associated Immunosuppressive Myeloid Cells

@inproceedings{Espagnolle2014SpecificIO,
  title={Specific Inhibition of the VEGFR-3 Tyrosine Kinase by SAR131675 Reduces Peripheral and Tumor Associated Immunosuppressive Myeloid Cells},
  author={Nicolas Espagnolle and Pauline Barron and Marie Mandron and Isabelle Blanc and Jacques Bonnin and Magali Agnel and Erwan Kerbelec and Jean Pascal Herault and Pierre Savi and Françoise Bono and Antoine Alam},
  booktitle={Cancers},
  year={2014}
}
Myeloid derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs) represent prominent components in cancer progression. We previously showed that inhibition of the VEGFR-3 pathway by SAR131675 leads to reduction of TAM infiltration and tumor growth. Here, we found that treatment with SAR131675 prevents the accumulation of immunosuppressive blood and splenic MDSCs which express VEGFR-3, in 4T1 tumor bearing mice. Moreover we showed that soluble factors secreted by tumor cells… CONTINUE READING

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