Specific HLA-DRB and -DQB alleles and haplotypes confer disease susceptibility or resistance in Bahraini type 1 diabetes patients.

@article{AlHarbi2004SpecificHA,
  title={Specific HLA-DRB and -DQB alleles and haplotypes confer disease susceptibility or resistance in Bahraini type 1 diabetes patients.},
  author={Einas M. Al-Harbi and Abdul-Jabbar Abbassi and Hala M. Tamim and Fayza al-Jenaidi and Mariam Kooheji and Madeeha Kamal and Salwa al-Mahroos and Faisal al-Nasir and Ayesha A Motala and Wassim Youssef Almawi},
  journal={Clinical and diagnostic laboratory immunology},
  year={2004},
  volume={11 2},
  pages={292-6}
}
Insofar as genetic susceptibility to type 1 diabetes is associated with HLA class II genes, with certain allelic combinations conferring disease susceptibility or resistance, this study assessed the distributions of HLA-DR and -DQ among 107 unrelated patients with type 1 diabetes and 88 healthy controls from Bahrain, all of Arab origin. The HLA-DRB and -DQB genotypes were determined by PCR-sequence-specific priming. The following alleles showed the strongest association with type 1 diabetes… CONTINUE READING