Specific Enzymic Methylation of an Arginine in the Experimental Allergic Encephalomyelitis Protein from Human Myelin

@article{Baldwin1971SpecificEM,
  title={Specific Enzymic Methylation of an Arginine in the Experimental Allergic Encephalomyelitis Protein from Human Myelin},
  author={Graham S Baldwin and Patrick R. Carnegie},
  journal={Science},
  year={1971},
  volume={171},
  pages={579 - 581}
}
A cytoplasmic enzyme from guinea pig brain was shown to transfer methyl groups from S-adenosylmethionine to only one of 19 arginine residues in the basic protein from human brain. The products were ω-N-monomethylarginine and ω-N,N'-dimethylarginine. These methylated arginines are adjacent to the main encephalitogenic determinant in the protein. Methylation may aid in the transfer of this region of the protein into the nonpolar environment within myelin and in maintaining the integrity of myelin… 
METHYLATION OF MYELIN BASIC PROTEIN BY ENZYMES FROM RAT BRAIN
Abstract— In rat brain Methylase l activity (S‐adenosyl‐l‐methionine: protein‐arginine methyl‐transferase) is found predominantly in the cytoplasmic fraction, and it appears that several enzymes
Biological methylation of myelin basic protein: enzymology and biological significance.
Enzymatic methylation of arginine residue in myelin basic protein.
TLDR
This article is focused mainly on the relationship between protein-arginine methylation and the myelin basic protein (MBP).
The Relationship of Myelin Basic Protein (Arginine) Methyltransferase to Myelination in Mouse Spinal Cord
TLDR
A comparison of myelin basic protein methylase with histone methylase activity during development indicates that each is a distinct, specific enzyme activity.
In Vivo Methylation of an Arginine in Chicken Myelin Basic Protein
TLDR
NG‐monomethylarginine was easily separated from the dimethylarginines, and as it was derived from myelin basic protein, it may be a good marker for myelinbasic protein turnover in vivo.
PROTEIN METHYLATION BY CEREBRAL TISSUE
TLDR
Transfer of the methyl group of S‐adenosyl [Me‐14C]methionine into cerebral proteins, an encephalitogenic protein and histones was studied using extracts of bovine and rat brains to study the enzymic properties.
The NG‐methylated arginine content of rat myelin during development
TLDR
The present work was undertaken to study possible changes in the methylation pattern of myelin during the development of the rat and the methylarginine content of human and bovine MBP prepared by various methods is presented.
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