Specific Effects of an Amnesic Drug: Effect of Lorazepam on Study Time Allocation and on Judgment of Learning

  title={Specific Effects of an Amnesic Drug: Effect of Lorazepam on Study Time Allocation and on Judgment of Learning},
  author={Marie Izaute and Elisabeth Bacon},
We investigated the effects of lorazepam, a benzodiazepine, on the allocation of study time, memory, and judgment of learning, in a cognitive task where the repetition of word presentation was manipulated. The aim was to assess whether lorazepam would affect the learning processes and/or whether the participants would be aware of the amnesic difficulty. A total of 30 healthy volunteers participated in the study, 15 of whom received a capsule containing the lorazepam drug (0.038 mg/kg) and 15 a… 

Drugs, memory, and metamemory: a dose-effect study with lorazepam and scopolamine.

Results provide evidence for a pharmacological dissociation between effects on memory versus metamemory (relative accuracy of item-by-item monitoring) across a range of levels of memory performance and suggest that the drugs selectively impair those aspects of metamnemonic monitoring that require participants' awareness of their overall current state of functioning.

Effects of the amnesic drug lorazepam on complete and partial information retrieval and monitoring accuracy

When studying four-letter nonsense letter strings, lorazepam participants present an impairment of episodic short-term memory and the drug has an effect on FOK estimates but not on the predictive accuracy of the FOK.

Dose effects of triazolam and scopolamine on metamemory.

Results suggested that both drugs impaired monitoring as reflected in absolute accuracy measures (impaired calibration in the direction of overconfidence) and control (the relationship between confidence and behavior).

Further Insight into Cognitive and Metacognitive Processes of the Tip-of-the-Tongue State with an Amnesic Drug as Cognitive Tool

The tip-of-the-tongue (TOT) state may be viewed as temporary and reversible micro-amnesia. Amnesic drugs, such as benzodiazepines, may be used as tools to reveal functional principles of normal

Pharmacodynamic and pharmacokinetic effects of TPA023, a GABAA α2,3 subtype-selective agonist, compared to lorazepam and placebo in healthy volunteers

The results show that the effect profile of TPA023 differs markedly from that of Lorazepam, at doses that were equipotent with regard to effects on saccadic peak veLocity, and these differences reflect the selectivity of T PA023 for different GABAA receptor subtypes.

Differential Neural Correlates Underlie Judgment of Learning and Subsequent Memory Performance

During encoding, those judged as “will be remembered” showed stronger activities in the default-mode network, including the ventromedial prefrontal cortex (PFC) and posterior cingulate cortex, as well as weaker functional connectivity between the left dorsolateral PFC and the visual cortex.

Pharmacodynamic and pharmacokinetic effects of MK-0343, a GABAA α2,3 subtype selective agonist, compared to lorazepam and placebo in healthy male volunteers

Although less effect on VAs alertness was expected, diminished effects on memory and postural stability were present and clinical studies in anxiety patients should show whether this dose of MK-0343 is therapeutically effective with a different side-effect profile.

The neural basis of metacognitive ability

  • S. FlemingR. Dolan
  • Psychology, Biology
    Philosophical Transactions of the Royal Society B: Biological Sciences
  • 2012
The psychological and neural underpinnings of metacognitive accuracy are reviewed, and a neural synthesis in which dorsolateral and anterior prefrontal cortical subregions interact with interoceptive cortices (cingulate and insula) to promote accurate judgements of performance is proposed.

The pharmacokinetic and pharmacodynamic effects of SL65.1498, a GABA-A 2,3 selective agonist, in comparison with lorazepam in healthy volunteers

This study showed that the three doses of SL65.1498 were well tolerated and induced no impairments on memory, sedation, psychomotor, and cognitive functions, which are believed to be mediated by the alpha1 and alpha5 subtypes.

Metamemory in schizophrenia: Retrospective confidence ratings interact with neurocognitive deficits



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Preliminary results suggest that chlorpromazine and lorazepam induced a double dissociation between priming and the acquisition of a cognitive routine, providing evidence that the two forms of implicit memory rely upon distinct neurochemical systems, the latter, but not the former, being dependent upon dopaminergic systems.

An investigation of the effects of benzodiazepine receptor ligands and of scopolamine on conceptual priming

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Lorazepam and scopolamine: A single-dose comparison of effects on human memory and attentional processes.

At the studied doses, lorazepam and scopolamine produced similar decrements in psychomotor performance, free recall, and overall sensitivity in distinguishing between studied and nonstudied items on a recognition memory test.

Differential amnesic properties of benzodiazepines: a dose-response comparison of two drugs with similar elimination half-lives

It is concluded that drugs with similar half-lives may have similar effects on some cognitive and mood factors but be completely different in terms of amnesic effects, andDiffering potencies of the two drugs may be a more important factor determining amnesia side-effects.

Time course of the effects of diazepam and lorazepam on perceptual priming and explicit memory

Contamination by explicit memory could account for the decrease in priming performance observed in the diazepam groups, which was maximal at the theoretical peak plasma concentration.

Differential effects of diazepam and lorazepam on repetition priming in healthy volunteers

The results indicate that the two benzodiazepines have differential amnestic effects, and it is suggested that these differential effects could be accounted for by a different cortical distribution of the twoBenzodiazepine.

Is lorazepam-induced amnesia specific to the type of memory or to the task used to assess it?

Retrieval tasks can be classified along a continuum from conceptually driven (relying on the encoded meaning of the material) to data driven (relying on the perceptual record and surface features of

Lorazepam, sedation, and conscious recollection: a dose-response study with healthy volunteers

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Pharmacokinetic and Pharmacodynamic Analysis of Sedative and Amnesic Effects of Lorazepam in Healthy Volunteers

Results suggest that the tests performed in this study represent sensitive measurements of the effects of lorazepam on the central nervous system, and the parameter values derived from pharmacokinetic and pharmacodynamic modeling, especially, the EC50 values, may provide sensitive indices that can be used to compare thecentral nervous system effects of benzodiazepines.

Benzodiazepine effects on memory tests: dependence on retrieval cues?

It is concluded that whether BZs impair performance on memory tasks depends more on the cues given at retrieval than the retrieval instructions (direct/indirect).