Specific Dysregulation of IFNγ Production by Natural Killer Cells Confers Susceptibility to Viral Infection

Abstract

Natural Killer (NK) cells contribute to the control of viral infection by directly killing target cells and mediating cytokine release. In C57BL/6 mice, the Ly49H activating NK cell receptor plays a key role in early resistance to mouse cytomegalovirus (MCMV) infection through specific recognition of the MCMV-encoded MHC class I-like molecule m157 expressed… (More)
DOI: 10.1371/journal.ppat.1004511

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