Specific DNA structural attributes modulate platinum anticancer drug site selection and cross-link generation

@inproceedings{Wu2011SpecificDS,
  title={Specific DNA structural attributes modulate platinum anticancer drug site selection and cross-link generation},
  author={Bin Wu and Gabriela E. Davey and Alexey A. Nazarov and Paul J Dyson and Curt A. Davey},
  booktitle={Nucleic acids research},
  year={2011}
}
  • Bin Wu, Gabriela E. Davey, +2 authors Curt A. Davey
  • Published in Nucleic acids research 2011
  • Medicine, Biology
  • Heavy metal compounds have toxic and medicinal potential through capacity to form strong specific bonds with macromolecules, and the interaction of platinum drugs at the major groove nitrogen atom of guanine bases primarily underlies their therapeutic activity. By crystallographic analysis of transition metal-and in particular platinum compound-DNA site selectivity in the nucleosome core, we establish that steric accessibility, which is controlled by specific structural parameters of the double… CONTINUE READING

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