Specific Calcium Antagonists in the Treatment of Peripheral Vascular Disease

  title={Specific Calcium Antagonists in the Treatment of Peripheral Vascular Disease},
  author={M. B. Emanuel},
  pages={454 - 469}
  • M. Emanuel
  • Published 1 July 1979
  • Medicine, Biology, Chemistry
  • Angiology
The antivasoconstrictor activity of the drugs cinnarizine and flunarizine is considered in relation to their inhibitory action on calcium ion flux mechanisms. Their clinical efficacy in peripheral vascular disease is reviewed, and the possible mode of action of the two drugs is discussed in relation to their described pharmacologic effects. 
Calcium entry blockers in the treatment of peripheral obliterative arterial disease
Important pharmaco-clinical criteria for selecting calcium entry blockers useful in the treatment of peripheral obliterative arterial disease (POAD) seem to be: 1. potent antivasoconstrictor
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Pharmacological Agents Affecting Emesis
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Protection by Flunarizine against Endothelial Cell Injury in vivo
The protection by flunarizine against endothelial injury may be related to its Ca2+-antagonistic properties and the compound does not affect platelet function, plasma coagulation or generation of PGI2 by vascular tissue and does not impair normal haemostasis at effective doses.
Effect of Calcium-Entry-Blockers on Arterioles, Capillaries, and Venules of the Retina
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Cinnarizine—a labyrinthine sedative
  • G. Towse
  • Biology
    The Journal of Laryngology & Otology
  • 1980
The role of cinnarizine in the management of motion sickness and Vertigo is reviewed.
Fixed combination of cinnarizine and dimenhydrinate versus betahistine dimesylate in the treatment of Ménière's disease: a randomized, double-blind, parallel group clinical study.
The combination preparation proved to be a highly efficient and safe treatment option for Ménière's disease and may be used both in the management of acute episodes and in long-term treatment.
Inhibition of smooth muscle cell proliferation and endothelial permeability with flunarizine in vitro and in experimental atheromas
  • E. Betz, H. Hämmerle, T. Strohschneider
  • Biology, Medicine
    Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie
  • 1985
It can be concluded that Flunarizine exerts its inhibitory action not only by its effect on the permeation through the endothelial lining but by a combined action on permeability and proliferation of cells in the artery wall.
1,4‐Dihydropyridine Ca2+ channel antagonists and activators: A comparison of binding characteristics with pharmacology
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Cinnarizine in the Treatment of Peripheral Vascular Disease: Mechanisms Related to its Clinical Action
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Proceedings: Inhibition by cinnarizine of calcium channels opening in depolarized smooth muscle.
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Effect of flunarizine on calcium-induced responses of peripheral vascular smooth muscle.
The present experiments suggest that flunarizine inhibits peripheral vasoconstriction by selectively decreasing the rate of stimulated Ca2+-influx, without affecting the myogenic activity of the vascular smooth muscle cells.
Prognostic Significance of Rheological and Biochemical Findings in Patients with Intermittent Claudication
There was a significant correlation between progressive deterioration of the peripheral circulatory disturbance and the initial blood viscosity, the plasma fibrinogen level, and the susceptibility of red cell lipids to autoxidation.
Influence of cinnarizine on the labyrinth and on vertigo
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Effect of certain drugs on the incidence of seasickness
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Clinical, Haemodynamic, Rheological, and Biochemical Findings in 126 Patients with Intermittent Claudication
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The conception has arisen that the amount of exercise necessary to produce pain in intermittent claudication is a measure of the extent to which the normal increase in muscle blood-flow with exercise is restricted by organic arterial obstruction.