Specific, major histocompatibility complex-unrestricted recognition of tumor-associated mucins by human cytotoxic T cells.

@article{Barnd1989SpecificMH,
  title={Specific, major histocompatibility complex-unrestricted recognition of tumor-associated mucins by human cytotoxic T cells.},
  author={Donna L. Barnd and Michael S Lan and Richard S. Metzgar and Olivera Olja J Finn},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1989},
  volume={86 18},
  pages={
          7159-63
        }
}
We have previously reported the establishment of cytotoxic T-cell lines from pancreatic cancer patients, by continuously stimulating tumor-draining lymph node cells with allogeneic pancreatic tumor cell lines. After the preliminary characterization of their phenotype and tumor specificity, detailed studies performed with one of the cell lines, W.D., show that it recognizes a specific antigen, a large and heavily glycosylated mucin molecule, expressed on pancreatic and breast tumors and tumor… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 178 CITATIONS, ESTIMATED 62% COVERAGE

Making the most of mucin: a novel target for tumor immunotherapy

  • Cancer Immunology, Immunotherapy
  • 1996
VIEW 9 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Relevance of the T cell receptor for immunotherapy of cancer

  • Cancer Immunology, Immunotherapy
  • 1994
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

1991
2018

CITATION STATISTICS

  • 7 Highly Influenced Citations