Specific, Sensitive, and Quantitative Enzyme-Linked Immunosorbent Assay for Human Immunoglobulin G Antibodies to Anthrax Toxin Protective Antigen

  title={Specific, Sensitive, and Quantitative Enzyme-Linked Immunosorbent Assay for Human Immunoglobulin G Antibodies to Anthrax Toxin Protective Antigen},
  author={C. Quinn and V. Semenova and C. Elie and S. Romero-Steiner and C. Greene and H. Li and K. Stamey and E. Steward‐Clark and D. S. Schmidt and E. Mothershed and Janet M. Pruckler and S. Schwartz and R. Benson and L. Helsel and P. Holder and S. E. Johnson and M. Kellum and T. Messmer and W. Thacker and L. Besser and B. Plikaytis and T. Taylor and A. E. Freeman and Kelly J. Wallace and P. Dull and J. Sejvar and E. Bruce and R. Moreno and A. Schuchat and J. Lingappa and S. Martin and J. Walls and M. Bronsdon and G. Carlone and Mary Bajani-Ari and D. Ashford and D. Stephens and B. Perkins},
  journal={Emerging Infectious Diseases},
  pages={1103 - 1110}
  • C. Quinn, V. Semenova, +35 authors B. Perkins
  • Published 2002
  • Biology, Medicine
  • Emerging Infectious Diseases
  • The bioterrorism-associated human anthrax epidemic in the fall of 2001 highlighted the need for a sensitive, reproducible, and specific laboratory test for the confirmatory diagnosis of human anthrax. The Centers for Disease Control and Prevention developed, optimized, and rapidly qualified an enzyme-linked immunosorbent assay (ELISA) for immunoglobulin G (IgG) antibodies to Bacillus anthracis protective antigen (PA) in human serum. The qualified ELISA had a minimum detection limit of 0.06 µg… CONTINUE READING
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