Species variation in the response of the cytochrome P-450-dependent monooxygenase system to inducers and inhibitors.

@article{Boobis1990SpeciesVI,
  title={Species variation in the response of the cytochrome P-450-dependent monooxygenase system to inducers and inhibitors.},
  author={Alan R Boobis and Dorothea Sesardic and Bryan P. Murray and Robert J. Edwards and A M Singleton and Kristin Rich and Stephen Murray and Rafael de la Torre and Jordi Segura and Olavi Pelkonen},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={1990},
  volume={20 11},
  pages={1139-61}
}
1. In the safety evaluation of drugs and other chemicals it is important to evaluate their possible inducing and inhibitory effects on the enzymes of drug metabolism. 2. While many similarities exist between species in their response to inducers and inhibitors, there are also important differences. Possible mechanisms of such variation are considered, with particular reference to the cytochrome P-450 system. 3. Differences in inhibition may be due to differences in inhibitory site of the enzyme… CONTINUE READING

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