Species variation in the genotoxicity of batracylin.


Batracylin (8-aminoisoindolo[1,2-b]quinazolin-12(10H)-one), an experimental chemotherapeutic agent, is a heterocyclic aryl amine. The presence of the free amino group suggests that this compound may be a carcinogen. Since many carcinogens or their product interact with DNA, the genotoxicity of batracylin was evaluated. The mutagenicity of batracylin was… (More)


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