Species variants of the IsK protein: differences in kinetics, voltage dependence, and La3+ block of the currents expressed in Xenopus oocytes.

@article{Hice1994SpeciesVO,
  title={Species variants of the IsK protein: differences in kinetics, voltage dependence, and La3+ block of the currents expressed in Xenopus oocytes.},
  author={Rita E. Hice and Kimberly Folander and Joseph J. Salata and Jeffrey S Smith and Michael C Sanguinetti and Robert James Swanson},
  journal={Pflugers Archiv : European journal of physiology},
  year={1994},
  volume={426 1-2},
  pages={139-45}
}
We have compared the slowly activating K+ currents (IsK) resulting from the expression of the human, mouse, or rat IsK proteins in Xenopus oocytes, utilizing natural, species-dependent sequence variations to initiate structure-function studies of this channel. Differences were found between the human and rodent currents in their voltage dependence, kinetics, and sensitivity to external La3+. The current/voltage relationships of the human and rat IsK currents differed significantly, with greater… CONTINUE READING

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