Species-specificity of monocyte chemotactic protein-1 and -3.

  title={Species-specificity of monocyte chemotactic protein-1 and -3.},
  author={Walter Luini and Silvano Sozzani and Jo Van Damme and Alberto Mantovani},
  volume={6 1},
The present study was aimed at defining the activity of human and mouse monocyte chemotactic protein-1 (MCP-1) on homologous and heterologous mononuclear phagocytes. Human natural and recombinant MCP-1 and mouse natural MCP-1/JE were tested as chemoattractants on human blood monocytes and mouse peritoneal macrophages. The human and murine cytokines were equiactive on human monocytes. Human MCP-1 was active on mouse macrophages but the maximal chemotactic effect elicited was about half that of… CONTINUE READING


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