Species-specific regulation of Toll-like receptor 3 genes in men and mice.

  title={Species-specific regulation of Toll-like receptor 3 genes in men and mice.},
  author={Sven Heinz and Viola Haehnel and Marina Karaghiosoff and Lucia Schwarzfischer and Mathias Mueller and Stefan W Krause and Michael Rehli},
  journal={The Journal of biological chemistry},
  volume={278 24},
Toll-like receptor 3 (TLR3) belongs to a family of evolutionary conserved innate immune recognition molecules and recognizes double-stranded RNA, a molecular pattern associated with viral infections. Earlier studies suggested a differential expression pattern in men and mice; the molecular basis for this observation, however, was unknown. Here we demonstrate that species-specific differences in tissue expression and responses to lipopolysaccaride (LPS) coincide with the presence of different… CONTINUE READING