Species-specific induction of cytochrome P-450 4A RNAs: PCR cloning of partial guinea-pig, human and mouse CYP4A cDNAs.

@article{Bell1993SpeciesspecificIO,
  title={Species-specific induction of cytochrome P-450 4A RNAs: PCR cloning of partial guinea-pig, human and mouse CYP4A cDNAs.},
  author={David R. Bell and Nick J. Plant and C G Rider and Lixin Na and Stanley Brown and I Ateitalla and Subrat kumar Acharya and M. W. Humphrey Davies and Elias A. Elias and Nancy A. Jenkins},
  journal={The Biochemical journal},
  year={1993},
  volume={294 ( Pt 1)},
  pages={
          173-80
        }
}
PCR was used to demonstrate the presence of a conserved region and to clone novel members of the cytochrome P-450 4A gene family from guinea pig, human and mouse cDNAs. This strategy is based on the sequences at nucleotides 925-959 and at the haem binding domain (nucleotides 1381-1410) of the rat CYP4A1 gene. Murine Cyp4a clones showed high sequence identity with members of the rat gene family, but CYP4A clones from human and guinea pig were equally similar to the rat/mouse genes, suggesting… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 22 CITATIONS

Similar Papers

Loading similar papers…