Species-specific homing mechanisms of human prostate cancer metastasis in tissue engineered bone.

@article{Holzapfel2014SpeciesspecificHM,
  title={Species-specific homing mechanisms of human prostate cancer metastasis in tissue engineered bone.},
  author={Boris Michael Holzapfel and Ferdinand Wagner and D Loessner and Nina Pauline Holzapfel and Laure Thibaudeau and Ross Crawford and M T P Ling and Judith Ann Clements and P. J. Russell and Dietmar Werner Hutmacher},
  journal={Biomaterials},
  year={2014},
  volume={35 13},
  pages={4108-15}
}
The development of effective therapeutic strategies against prostate cancer bone metastases has been impeded by the lack of adequate animal models that are able to recapitulate the biology of the disease in humans. Bioengineered approaches allow researchers to create sophisticated experimentally and physiologically relevant in vivo models to study interactions between cancer cells and their microenvironment under reproducible conditions. The aim of this study was to engineer a morphologically… CONTINUE READING
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