Species-specific control of cellular proliferation and the impact of large animal models for the use of olfactory ensheathing cells and Schwann cells in spinal cord repair

@article{Wewetzer2011SpeciesspecificCO,
  title={Species-specific control of cellular proliferation and the impact of large animal models for the use of olfactory ensheathing cells and Schwann cells in spinal cord repair},
  author={Konstantin Wewetzer and Christine Radtke and Jeffery Kocsis and Wolfgang Baumgaertner},
  journal={Experimental Neurology},
  year={2011},
  volume={229},
  pages={80-87}
}
Autologous transplantation of olfactory ensheathing cells (OECs) and Schwann cells (SCs) is considered a promising option to promote axonal regrowth and remyelination after spinal cord injury in humans. However, if the experimental data from the rodent model can be directly extrapolated to humans, as widely believed, remains to be established. While limitations of the rodent system have recently been discussed with regard to the distinct organization of the motor systems, the question whether… CONTINUE READING
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