Species-specific assessment of Mycobacterium leprae in skin biopsies by in situ hybridization and polymerase chain reaction.

@article{Arnoldi1992SpeciesspecificAO,
  title={Species-specific assessment of Mycobacterium leprae in skin biopsies by in situ hybridization and polymerase chain reaction.},
  author={J{\"o}rg Arnoldi and Claudia Schlueter and Michael Duchrow and Ludwig H{\"u}bner and Manfred Ernst and Andreas Teske and H. D. Flad and Johannes Gerdes and Erik C B{\"o}ttger},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  year={1992},
  volume={66 5},
  pages={618-23}
}
Conventional histopathologic diagnosis of mycobacterial infections are limited to the determination of "acid-fast bacilli". A species-specific diagnosis is thus far impossible. In addition, routine microbiologic assessments of mycobacteria suffer from the major drawback that a species-specific diagnosis is extremely time-consuming and in several cases even impossible. As Mycobacterium leprae cannot be cultured in vitro, we tried to specifically target this obligate intracellular parasite by in… CONTINUE READING
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