Species-specific Regulation of Toll-like Receptor 3 Genes in Men and Mice*

  title={Species-specific Regulation of Toll-like Receptor 3 Genes in Men and Mice*},
  author={Sven Heinz and Viola Haehnel and M. Karaghiosoff and L. Schwarzfischer and M. M{\"u}ller and S. Krause and M. Rehli},
  journal={Journal of Biological Chemistry},
  pages={21502 - 21509}
  • Sven Heinz, Viola Haehnel, +4 authors M. Rehli
  • Published 2003
  • Medicine, Biology
  • Journal of Biological Chemistry
  • Toll-like receptor 3 (TLR3) belongs to a family of evolutionary conserved innate immune recognition molecules and recognizes double-stranded RNA, a molecular pattern associated with viral infections. Earlier studies suggested a differential expression pattern in men and mice; the molecular basis for this observation, however, was unknown. Here we demonstrate that species-specific differences in tissue expression and responses to lipopolysaccaride (LPS) coincide with the presence of different… CONTINUE READING
    Of Mice and Not Men: Differences between Mouse and Human Immunology
    • 2,275
    • Open Access
    TLR Signaling Tailors Innate Immune Responses in Human Microglia and Astrocytes1
    • 577
    • Open Access
    Transcriptional signaling by double-stranded RNA: role of TLR3.
    • 253
    Preferential expression and function of Toll-like receptor 3 in human astrocytes
    • 245
    Sensing of Viral Infection and Activation of Innate Immunity by Toll-Like Receptor 3
    • 250
    • Open Access


    Publications referenced by this paper.