Species-specific Regulation of Toll-like Receptor 3 Genes in Men and Mice*

@article{Heinz2003SpeciesspecificRO,
  title={Species-specific Regulation of Toll-like Receptor 3 Genes in Men and Mice*},
  author={Sven Heinz and Viola Haehnel and M. Karaghiosoff and L. Schwarzfischer and M. M{\"u}ller and S. Krause and M. Rehli},
  journal={Journal of Biological Chemistry},
  year={2003},
  volume={278},
  pages={21502 - 21509}
}
  • Sven Heinz, Viola Haehnel, +4 authors M. Rehli
  • Published 2003
  • Medicine, Biology
  • Journal of Biological Chemistry
  • Toll-like receptor 3 (TLR3) belongs to a family of evolutionary conserved innate immune recognition molecules and recognizes double-stranded RNA, a molecular pattern associated with viral infections. Earlier studies suggested a differential expression pattern in men and mice; the molecular basis for this observation, however, was unknown. Here we demonstrate that species-specific differences in tissue expression and responses to lipopolysaccaride (LPS) coincide with the presence of different… CONTINUE READING
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