Species-restricted antibody response against a DNA-construct coding for aspartic proteinase from Schistosoma japonicum

@article{Chlichlia2001SpeciesrestrictedAR,
  title={Species-restricted antibody response against a DNA-construct coding for aspartic proteinase from Schistosoma japonicum},
  author={Katerina Chlichlia and Mahmoud Bahgat and Volker Schirrmacher and Andreas Ruppel},
  journal={Parasitology Research},
  year={2001},
  volume={88},
  pages={368-375}
}
DNA-based vaccine technology was used to immunize against the schistosome digestive enzyme, cathepsin D aspartic proteinase. The cDNA coding for Schistosoma japonicum aspartic proteinase was cloned in a mammalian expression vector under control of the CMV promoter/enhancer and expressed for the first time in transfected mammalian cells as well as in mice… CONTINUE READING