Species differences in vacuolation of the choroid plexus induced by the piperidine-ring drug disobutamide in the rat, dog, and monkey.

  title={Species differences in vacuolation of the choroid plexus induced by the piperidine-ring drug disobutamide in the rat, dog, and monkey.},
  author={Haruko Koizumi and M. Watanabe and Hiroaki Numata and Toshiharu Sakai and Hiroshi Morishita},
  journal={Toxicology and applied pharmacology},
  volume={84 1},

In vitro and in vivo ultrastructural changes induced by macrolide antibiotic LY281389.

It is indicated that LY281389 can induce similar phospholipidosis-like vacuolar changes in rat and dog muscle and in a cultured rat muscle cell line, and positive acid phosphatase staining of drug-induced vacuoles seen in vitro and in vivo are lysosomal in origin.

The susceptibility of various cultured cells to induction of clear cytoplasmic vacuoles by disobutamide.

Interstitial Adipocytes in the Beagle Dog and New Zealand White Rabbit Choroid Plexus

It is proposed that the interstitial adipocytes should not be recorded as a finding in preclinical studies unless the adipocytes are altered spontaneously (ie, lipoma) or after xenobiotic treatment.

The Distributional Nexus of Choroid Plexus to Cerebrospinal Fluid, Ependyma and Brain

Countering the physico-chemical and pathogenic insults to the homeostasis-mediating ventricle-bordering cells sustains brain health and fluid balance.

Proliferative and Nonproliferative Lesions of the Rat and Mouse Central and Peripheral Nervous Systems

This article recommends standardized terms for classifying changes observed in tissues of the mouse and rat central (CNS) and peripheral (PNS) nervous systems as well as principal toxicant-induced findings.

Alveolar proteinosis and phospholipidoses of the lungs.

  • G. Hook
  • Biology, Chemistry
    Toxicologic pathology
  • 1991
The status of phospholipid metabolism in the lungs during the process of each of these lung conditions has been reviewed and possible mechanisms for their establishment are discussed.

Toxicologic Pathology of the Eye: Histologic Preparation and Alterations of the Anterior Segment

This chapter focuses on the histologic preparation of ocular tissues and findings involving the anterior segment, uvea, and ocular adnexa and is followed by a chapter focusing on the lens and posterior segment of the eye.

Central Nervous System Stimulants Limit Caffeine Transport at the Blood–Cerebrospinal Fluid Barrier

The simultaneous presence of stimulants and caffeine inhibits caffeine transfer across the blood–cerebrospinal fluid barrier (BCSFB), and it is suggested that choroid plexus epithelial cells were involved in inhibiting the efflux of caffeine to the CSF.



Piperamide-induced morphological changes in the choroid plexus.

Drug-induced phospholipidoses. II. Tissue distribution of the amphiphilic drug chlorphentermine.

This review deals with drug-induced lipidoses and the possible underlying mechanisms, and some of the most severely affected tissues have been demonstrated to contain increased amounts of phospholipids and of the drug applied.

An ultrastructural study of opague cytoplasmic inclusions induced by triparanol treatment.

It is suggested that type IV cytoplasmic bodies are formed through the stages of type I (or type II) and type III, and that types I, II, and III in turn, form from hypertrophied smooth membranes.

Organic anion and cation transport in vitro by dog choroid plexus: effects of neuroleptics and tricyclic antidepressants.

  • E. Bárány
  • Psychology
    Acta pharmacologica et toxicologica
  • 1979
Dog lateral choroid plexus accumulates the cation 14C-emepronium and the divalent anion 125I-iodipamide in vitro and the accumulation is inhibited by neuroleptics and tricyclic antidepressants with an aliphatic side chain at 1--10 micron.

Drug Entry into Brain and Cerebrospinal Fluid

The barriers separating plasma from brain and cerebrospinal fluid (CSF) are complex systems involving passive and active transport and subserve a number of important functions and provide a path for clearance from deep within the brain of breakdown products of cellular metabolism.


A new type of fatty liver, in which a large amount of phospholipids deposited in the liver parenchymal cells, is presented, found in the patient with markedly enlarged liver and probably with some chronic inflammation.