Species differences in troxacitabine pharmacokinetics and pharmacodynamics: implications for clinical development.

Abstract

PURPOSE Troxacitabine is the first unnatural L-nucleoside analog to show potent preclinical antitumor activity and is currently under clinical investigation. Significant differences in troxacitabine toxicity between mice, rats, monkeys, and humans were observed during preclinical and clinical evaluations. To better understand the different toxicity and… (More)

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