Corpus ID: 25948474

Species differences in the kinetics and metabolism of fenfluramine isomers.

@article{Caccia1982SpeciesDI,
  title={Species differences in the kinetics and metabolism of fenfluramine isomers.},
  author={Silvio Caccia and Marzia Ballabio and Giovanna Guiso and Maurizio Rocchetti and Silvio Garattini},
  journal={Archives internationales de pharmacodynamie et de therapie},
  year={1982},
  volume={258 1},
  pages={
          15-28
        }
}
  • Silvio Caccia, Marzia Ballabio, +2 authors Silvio Garattini
  • Published in
    Archives internationales de…
    1982
  • Chemistry, Medicine
  • After single oral doses of racemic fenfluramine to man and animals (male CD-COBS Sprague-Dawley rat, male CD1-COBS mice and male beagle dogs) plasma and/or brain concentrations of the d- and l-isomers and their deethylated metabolite were measured by gas-liquid chromatography. In rat and mouse d-fenfluramine had a longer half-life (T 1/2) and gave a larger area under the curve (AUC) than the l-isomer. These differences were consistent with stereoselective N-deethylation of l-fenfluramine. Thus… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 11 CITATIONS

    A Developmental Toxicology Assay Platform for Screening Teratogenic Liability of Pharmaceutical Compounds.

    VIEW 1 EXCERPT
    CITES BACKGROUND

    The anorectic effect of fenfluramine is influenced by sex and stage of the estrous cycle in rats.

    VIEW 1 EXCERPT
    CITES METHODS

    Comparative studies on the anorectic activity of d-fenfluramine in mice, rats, and guinea pigs

    VIEW 2 EXCERPTS
    CITES BACKGROUND & RESULTS