Species differences in the glutathione transferase GSTT1-1 activity towards the model substrates methyl chloride and dichloromethane in liver and kidney

@article{Thier1998SpeciesDI,
  title={Species differences in the glutathione transferase GSTT1-1 activity towards the model substrates methyl chloride and dichloromethane in liver and kidney},
  author={Ricarda Thier and Frederike A. Wiebel and Andreas Hinkel and Andreas Burger and Thomas Br{\"u}ning and Konrad Morgenroth and Theodor Senge and Michael Wilhelm and Thomas Gerhard Schulz},
  journal={Archives of Toxicology},
  year={1998},
  volume={72},
  pages={622-629}
}
Glutathione transferase (GST) GSTT1-1 is involved in the biotransformation of several chemicals widely used in industry, such as butadiene and dichloro methane DCM. The polymorphic hGSTT1-1 may well play a role in the development of kidney tumours after high and long-term occupational exposure against trichloroethylene. Although several studies have investigated the association of this polymorphism with malignant diseases little is known about its enzyme activity in potential extrahepatic… CONTINUE READING