Species differences in the binding kinetics of 25-hydroxyvitamin D3 to vitamin D binding protein.

@article{Vieth1990SpeciesDI,
  title={Species differences in the binding kinetics of 25-hydroxyvitamin D3 to vitamin D binding protein.},
  author={Reinhold Vieth and Matthew J Kessler and Kenneth P. H. Pritzker},
  journal={Canadian journal of physiology and pharmacology},
  year={1990},
  volume={68 10},
  pages={1368-71}
}
The specific binding of 25-hydroxyvitamin D3 to its binding protein was studied in serum of the human, rhesus monkey, cow, horse, and rat. The free fraction of 25-hydroxyvitamin D3 in the rat was 0.34 +/- 0.15 pmol free/nmol total (+/- SD) and this was lower than in any of the other species (p less than 0.01). In the human, the free fraction was 1.5 +/- 0.32 pmol free/nmol total, which was higher than in any of the other species (p less than 0.001). The differences in the free fraction were… CONTINUE READING