Species differences in the behavioral toxicity produced by intrathecal substance P antagonists: relationship to analgesia.

@article{Vaught1987SpeciesDI,
  title={Species differences in the behavioral toxicity produced by intrathecal substance P antagonists: relationship to analgesia.},
  author={Jeffry L. Vaught and Randy W. Scott},
  journal={Life sciences},
  year={1987},
  volume={40 2},
  pages={
          175-81
        }
}
Intrathecal administration of [D-Pro2,D-Trp7,9]-substance P to rats produced an irreversible flaccid paralysis of the hind limbs (paraplegia) which was irreversible with an ED50 of 2.3 micrograms. At 5 micrograms intrathecally, [D-Pro2,D-Phe7,D-Trp9]-substance P, [D-Trp7,9]-substance P and [D-Pro4,D-Trp7,9,10]-substance P octapeptide also produced paraplegia (70-80%). Surprisingly, intrathecal administration of up to 20 micrograms of these analogs to the mouse produced no paraparesis or… CONTINUE READING

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