Species differences in renal Src activity direct EGF receptor regulation in life or death response to EGF.

@article{Kiley2007SpeciesDI,
  title={Species differences in renal Src activity direct EGF receptor regulation in life or death response to EGF.},
  author={Susan C. Kiley and Robert L. Chevalier},
  journal={American journal of physiology. Renal physiology},
  year={2007},
  volume={293 3},
  pages={F895-903}
}
In rodent models of obstructive nephropathy, exogenous epidermal growth factor (EGF) attenuates tubule cell death in rats and exacerbates cell death in mice. To identify species differences in EGF receptor (EGFR) regulation and signaling, cell lysates were prepared from rat, mouse, and human proximal tubule cells (PTC) and compared by immunoblot analysis for expression and phosphorylation of Src and EGFR. Frozen kidney tissue was also analyzed. Results indicate mouse PTC have constitutive Src… CONTINUE READING

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