Species differences in phenazeram kinetics and metabolism

  title={Species differences in phenazeram kinetics and metabolism},
  author={Vladimir P. Zherdev and Silvio Caccia and Silvio Garattini and A. L. {\'E}konomov},
  journal={European Journal of Drug Metabolism and Pharmacokinetics},
The kinetic profiles of phenazepam and its hydroxylated derivative were compared in rat, dog, cat and man after administration of single oral doses of the parent compound. The absorption of phenazepam was reasonably rapid in all the species studied. Blood peak concentrations (Cmax) were reached at 1 h in rats (0.32 ± 0.03 μg/ml), at 0.5 h in dogs 0.54 ± 0… CONTINUE READING