Species differences in peroxisome proliferation; mechanisms and relevance.

@article{Choudhury2000SpeciesDI,
  title={Species differences in peroxisome proliferation; mechanisms and relevance.},
  author={Agharul I Choudhury and Surinder Chahal and A. R. Bell and Simon R. Tomlinson and Ruth Ann Roberts and Andrew M Salter and David R. Bell},
  journal={Mutation research},
  year={2000},
  volume={448 2},
  pages={
          201-12
        }
}
Peroxisome proliferators are a class of structurally diverse chemicals, which induce liver carcinogenesis in rodents through interaction and activation of the Peroxisome Proliferator-Activated Receptor alpha (PPARalpha). PPARalpha agonists elicit a powerful pleiotropic response, which include hypolipidaemia. We have examined the response of species that are classically unresponsive to peroxisome proliferators. Whereas hamster responds to PPARalpha agonists by hepatomegaly and induction of… CONTINUE READING

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