Species differences in mGluR5 binding sites in mammalian central nervous system determined using in vitro binding with [18F]F-PEB.

@article{Patel2007SpeciesDI,
  title={Species differences in mGluR5 binding sites in mammalian central nervous system determined using in vitro binding with [18F]F-PEB.},
  author={Shil Patel and Terence G. Hamill and Brett Connolly and Elaine M. Jagoda and Wenping Li and Raymond E. Gibson},
  journal={Nuclear medicine and biology},
  year={2007},
  volume={34 8},
  pages={1009-17}
}
Binding of [18F]3-fluoro-5-[(pyridin-3-yl)ethynyl]benzonitrile ([18F]F-PEB) was evaluated in membranes and tissue sections prepared from rat, rhesus and human brain. Saturation equilibrium binding experiments with frozen brain cortex and caudate-putamen membranes of young adult rhesus and human and with cortex and striatum from rat yielded data indicative of specific high-affinity binding (KD=0.1-0.15 nM, n> or =3) to a saturable site previously shown to be metabotropic glutamate receptor 5… CONTINUE READING
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