Species differences in hepatobiliary disposition of taurocholic acid in human and rat sandwich-cultured hepatocytes: implications for drug-induced liver injury.

Abstract

The bile salt export pump (BSEP) plays an important role in bile acid excretion. Impaired BSEP function may result in liver injury. Bile acids also undergo basolateral efflux, but the relative contributions of biliary (CLBile) versus basolateral efflux (CLBL) clearance to hepatocellular bile acid excretion have not been determined. In the present study… (More)
DOI: 10.1124/jpet.114.221564

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@article{Yang2015SpeciesDI, title={Species differences in hepatobiliary disposition of taurocholic acid in human and rat sandwich-cultured hepatocytes: implications for drug-induced liver injury.}, author={Kyunghee Yang and N. Pfeifer and Kathleen Koeck and Kim L. R. Brouwer}, journal={The Journal of pharmacology and experimental therapeutics}, year={2015}, volume={353 2}, pages={415-23} }