Species differences in distribution and prediction of human V(ss) from preclinical data.

Abstract

Prediction of human volume of distribution at steady state (V(ss)) before first administration of a new drug candidate to humans has become an important part of the drug development process. This study examines the assumptions behind interspecies scaling techniques used to predict human V(ss) from preclinical data, namely the equivalency of V(ss,u) and/or f… (More)
DOI: 10.1124/dmd.111.040766

Topics

Cite this paper

@article{Berry2011SpeciesDI, title={Species differences in distribution and prediction of human V(ss) from preclinical data.}, author={Loren M. Berry and Chao Li and Zhiyang Zhao}, journal={Drug metabolism and disposition: the biological fate of chemicals}, year={2011}, volume={39 11}, pages={2103-16} }