Species differences in TSIX/Tsix reveal the roles of these genes in X-chromosome inactivation.

@article{Migeon2002SpeciesDI,
  title={Species differences in TSIX/Tsix reveal the roles of these genes in X-chromosome inactivation.},
  author={Barbara Ruben Migeon and Catherine T H Lee and Ashis K Chowdhury and Heather Carpenter},
  journal={American journal of human genetics},
  year={2002},
  volume={71 2},
  pages={286-93}
}
Transcriptional silencing of the human inactive X chromosome is induced by the XIST gene within the human X-inactivation center. The XIST allele must be turned off on one X chromosome to maintain its activity in cells of both sexes. In the mouse placenta, where X inactivation is imprinted (the paternal X chromosome is always inactive), the maternal Xist allele is repressed by a cis-acting antisense transcript, encoded by the Tsix gene. However, it remains to be seen whether this antisense… CONTINUE READING
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