Species differences in GnRH activation of the LHβ promoter: role of Egr1 and Sp1

@article{Call2002SpeciesDI,
  title={Species differences in GnRH activation of the LHβ promoter: role of Egr1 and Sp1},
  author={Gerald B. Call and Michael W. Wolfe},
  journal={Molecular and Cellular Endocrinology},
  year={2002},
  volume={189},
  pages={85-96}
}
Activation of the luteinizing hormone beta (LHbeta) promoter by gonadotropin-releasing hormone (GnRH) via the transcription factor early growth response protein-1 (Egr1) has been well characterized. To determine the mechanisms affecting Egr1 regulation of LHbeta, we analyzed five different species of LHbeta promoters (equine, mouse, rat, bovine and human). Electrophoretic mobility shift assays (EMSAs) identified multiple transcription factors binding to the Egr regions on the LHbeta promoter… CONTINUE READING
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