Species differences in 5-HT autoreceptors.

  title={Species differences in 5-HT autoreceptors.},
  author={Gary W Price and Claire Roberts and Jeannette Watson and Michael J. Burton and K. F. Mulholland and Derek N. Middlemiss and Brian Joseph Jones},
  journal={Behavioural brain research},
  volume={73 1-2},
Release of 5-HT in the CNS is under the control of autoreceptors. These autoreceptors fall into two categories: cell body autoreceptors and terminal autoreceptors. The former inhibit 5-HT release through inhibition of cell firing; the latter through direct inhibition of release at the terminal. Cell body (or somatodendritic) autoreceptors belong to the 5-HT1A receptor subtype in all species studied so far. In the rat and mouse, the terminal autoreceptor is known to be a 5-HT1B receptor, whereas… CONTINUE READING

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