Species differences and the role of sodium-calcium exchange in cardiac muscle relaxation.

@article{Bers1991SpeciesDA,
  title={Species differences and the role of sodium-calcium exchange in cardiac muscle relaxation.},
  author={Donald M. Bers},
  journal={Annals of the New York Academy of Sciences},
  year={1991},
  volume={639},
  pages={375-85}
}
  • Donald M. Bers
  • Published 1991 in Annals of the New York Academy of Sciences
During normal relaxation in rabbit, guinea-pig, and rat ventricular muscle, the Na-Ca exchange system competes with the SR Ca pump, with the former being responsible for about 20-30% of the Ca removal from the cytoplasm. Ca extrusion via Na-Ca exchange is Em-sensitive, whereas Ca uptake by the SR is not. Neither the sarcolemmal Ca-ATPase pump nor mitochondrial Ca uptake appear to contribute significantly to the decline of [Ca]i during relaxation. Furthermore, the diastolic efflux of Ca from… CONTINUE READING

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