Species difference in the inhibition of drug metabolism by liver microsomes by different inhibitors.

@article{Kato1969SpeciesDI,
  title={Species difference in the inhibition of drug metabolism by liver microsomes by different inhibitors.},
  author={R. Kato and K. Onoda and M. Takayanagi},
  journal={Japanese journal of pharmacology},
  year={1969},
  volume={19 3},
  pages={
          438-50
        }
}
  • R. Kato, K. Onoda, M. Takayanagi
  • Published 1969
  • Chemistry, Medicine
  • Japanese journal of pharmacology
  • It has been reported that the activities of drug-metabolizing enzymes of liver microsomes are inhibited by different kind of drugs (1). SKF 525-A (β-diethylaminoethyl-diphenylpropylacetate HCl) was discovered for the first time and it has been known as the most popular and typical inhibitor of microsomal drug-metabolizing enzymes (2-4), while DPEA (2, 4-dichlorophenylphenoxyethylamine HCl) has been known as the most potent inhibitor (5-6). Moreover, Kato et al. (1, 7, 8) reported that the… CONTINUE READING
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    References

    SHOWING 1-8 OF 8 REFERENCES
    AND FELLOws
    • E.J.: J. Pharmac. exp. Ther. 111,
    • 1954
    AND MENNARING, G.J.: Biochem. Pharmac
    • 1964
    AXELROD, J. AND BRODIE, B.B.
    • J. Pharmac. exp. Ther. 112,
    • 1964
    CHIESARA, B. AND VASSANELLI, P.: Med
    • Exp. 6,
    • 1962
    CHIESARA, E. AND VASSANELLI, P.: Biochem. Pharmac
    • 1964
    REICHENTHAL, J. AND BRODIE, B.B.
    • J. Pharmac. exp. Ther. 112,
    • 1954
    VASSANELLI, P. AND CHIESARA
    • Experientia 18,
    • 1962
    VASSANELLI, P. AND CHIESARA, E.: Biochem. Pharmac
    • 1963