Species-dependent hemodynamic effects of adenosine A3-receptor agonists IB-MECA and Cl-IB-MECA.

@article{Lasley1999SpeciesdependentHE,
  title={Species-dependent hemodynamic effects of adenosine A3-receptor agonists IB-MECA and Cl-IB-MECA.},
  author={Robert D. Lasley and Prakash Narayan and M. Salik Jahania and Elizabeth L Partin and Kathleen R Kraft and Robert M. Mentzer},
  journal={The American journal of physiology},
  year={1999},
  volume={276 6},
  pages={
          H2076-84
        }
}
The purpose of this study was to compare the hemodynamic effects of the adenosine A3-receptor agonists N6-(3-iodobenzyl)-9-[5-(methylcarbamoyl)-beta-D-ribofuranosyl]aden ine (IB-MECA) and 2-chloro-N6-(3-iodobenzyl)-9-[5-(methylcarbamoyl)-beta-D-ribofu ranosy l]adenine (Cl-IB-MECA) in isolated rat and rabbit hearts and in the intact, open-chest pig. Isolated hearts perfused with Krebs-Henseleit buffer at a constant pressure (70 mmHg) were treated with 50 nM of either IB-MECA or Cl-IB-MECA… CONTINUE READING

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