Species and dose differences in the accumulation of imipramine by mammalian lungs.

@article{Drew1981SpeciesAD,
  title={Species and dose differences in the accumulation of imipramine by mammalian lungs.},
  author={Renee Drew and Zahid H. Siddik and Edward G. Mimnaugh and Theodore E. Gram},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1981},
  volume={9 4},
  pages={322-6}
}
Adult male mice, guinea pigs, rabbits, and rats were injected ip with 14C-imipramine (IP) at doses of either 10 or 50 mg/kg and killed 15 min or 12 hr later. Plasma, lung, liver, and kidney were analyzed for total radioactivity and for IP and desmethylimipramine (DMI). Neither mouse nor guinea pig lungs accumulated IP-derived 14C relative to the other tissues at either dose or time. Indeed, tissue/plasma (T/P) ratios for liver in these species exceeded those for lung. Rabbit and rat lung did… CONTINUE READING