Species adaptation in a protein molecule.

@article{Perutz1983SpeciesAI,
  title={Species adaptation in a protein molecule.},
  author={Max F. Perutz},
  journal={Molecular biology and evolution},
  year={1983},
  volume={1 1},
  pages={1-28}
}
The allosteric properties of hemoglobins, especially their responses to ligands other than oxygen, vary widely in different classes of vertebrates. Knowing the stereochemistry of the cooperative effects in human hemoglobin, one can infer the stereochemical basis of these variations from the changes in amino acid sequence. The results indicate that the tertiary and quaternary structures of deoxy- and oxyhemoglobin have remained almost invariant during vertebrate evolution and that most of the… CONTINUE READING
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