Species Variation in the Mechanisms of Mesenchymal Stem Cell‐Mediated Immunosuppression

@article{Ren2009SpeciesVI,
  title={Species Variation in the Mechanisms of Mesenchymal Stem Cell‐Mediated Immunosuppression},
  author={Guangwen Ren and Juanjuan Su and Liying Zhang and Xin Zhao and Weifang Ling and Andrew L'huillie and Jimin Zhang and Yongqing Lu and Arthur I. Roberts and Weizhi Ji and Huatang Zhang and Arnold B Rabson and Yufang Shi},
  journal={STEM CELLS},
  year={2009},
  volume={27}
}
Bone marrow‐derived mesenchymal stem cells (MSCs) hold great promise for treating immune disorders because of their immunoregulatory capacity, but the mechanism remains controversial. As we show here, the mechanism of MSC‐mediated immunosuppression varies among different species. Immunosuppression by human‐ or monkey‐derived MSCs is mediated by indoleamine 2,3‐dioxygenase (IDO), whereas mouse MSCs utilize nitric oxide, under the same culture conditions. When the expression of IDO and inducible… Expand
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