Species Used for Drug Testing Reveal Different Inhibition Susceptibility for 17beta-Hydroxysteroid Dehydrogenase Type 1

@inproceedings{Moeller2010SpeciesUF,
  title={Species Used for Drug Testing Reveal Different Inhibition Susceptibility for 17beta-Hydroxysteroid Dehydrogenase Type 1},
  author={Gabriele Moeller and Bettina Husen and Dorota Kowalik and Leena Hirvel{\"a} and Dariusz Plewczynski and Leszek Rychlewski and Josef Messinger and Hubert H. Thole and Jerzy Adamski},
  booktitle={PloS one},
  year={2010}
}
Steroid-related cancers can be treated by inhibitors of steroid metabolism. In searching for new inhibitors of human 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD 1) for the treatment of breast cancer or endometriosis, novel substances based on 15-substituted estrone were validated. We checked the specificity for different 17beta-HSD types and species. Compounds were tested for specificity in vitro not only towards recombinant human 17beta-HSD types 1, 2, 4, 5 and 7 but also against… CONTINUE READING

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