Species-Level Deconvolution of Metagenome Assemblies with Hi-C–Based Contact Probability Maps

@inproceedings{Burton2014SpeciesLevelDO,
  title={Species-Level Deconvolution of Metagenome Assemblies with Hi-C–Based Contact Probability Maps},
  author={Joshua N. Burton and Ivan Liachko and Maitreya J. Dunham and Jay Shendure},
  booktitle={G3},
  year={2014}
}
Microbial communities consist of mixed populations of organisms, including unknown species in unknown abundances. These communities are often studied through metagenomic shotgun sequencing, but standard library construction methods remove long-range contiguity information; thus, shotgun sequencing and de novo assembly of a metagenome typically yield a collection of contigs that cannot readily be grouped by species. Methods for generating chromatin-level contact probability maps, e.g., as… CONTINUE READING

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