Species Difference in M-Hydroxylation of a Tryptophan Pyrolysis Product in Relation to Mutagenic Activation 1

Metabolic activation of a tryptophan pyrolysate, 3-amino-1 methyl-5H-pyrido[4,3-D ]indole (Trp-P-2), in liver microsomes from rats, mice, hamsters, guinea pigs, and rabbits was studied to know whether AMiydroxylation is a common obligatory step for mutagenic activation of Trp-P-2. Among hepatic microsomes obtained from untreated animals, the highest… CONTINUE READING