Species Comparison of Pre-systemic Bioactivation of Vicagrel, a New Acetate Derivative of Clopidogrel

@inproceedings{Qiu2016SpeciesCO,
  title={Species Comparison of Pre-systemic Bioactivation of Vicagrel, a New Acetate Derivative of Clopidogrel},
  author={Zhi-xia Qiu and Wen-Chao Gao and Yu Dai and Su-feng Zhou and J. R. Zhao and Yang Lu and Xi-jing Chen and Ning Li},
  booktitle={Front. Pharmacol.},
  year={2016}
}
Previously we have found vicagrel, a new acetate derivative of clopidogrel, underwent hydrolysis to 2-oxo-clopidogrel and subsequent conversions to its pharmacological active metabolite (AM) and inactive carboxylic acid metabolite (CAM). This study demonstrated the interspecies differences of the vicagrel bioactivation by comparing the critical vicagrel metabolites formation in rats, dogs and human. The pharmacokinetic studies with rats and dogs were conducted after intragastric administration… CONTINUE READING
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