Speciation of antimony (III) and antimony (V) using hydride generation for meglumine antimoniate pharmaceutical formulations quality control.

@article{Cabral2008SpeciationOA,
  title={Speciation of antimony (III) and antimony (V) using hydride generation for meglumine antimoniate pharmaceutical formulations quality control.},
  author={L{\'u}cio Mendes Cabral and V{\^a}nia Neves Moreira Juliano and Luiza Rosario Sousa Dias and Camila Braga Dornelas and Carlos Rangel Rodrigues and Michele Villardi and Helena Carla Castro and T. C. dos Santos},
  journal={Memorias do Instituto Oswaldo Cruz},
  year={2008},
  volume={103 2},
  pages={
          130-7
        }
}
The pentavalent antimonies, mainly the meglumine antimoniate, are recommends as first-choice medicines for leishmaniasis therapy. In this work we described the development of formulations of meglumine antimoniate injectable medication, as well as the analytical methodology used in the selective determination of Sb(III) and Sb(Total) by hydride generation - inductively coupled plasma atomic emission spectrometry (HG-ICP-AES) and ICP-AES, respectively. On that purpose the analytical methodology… CONTINUE READING

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